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  • Title: [Use of an experimental design method for studying the effect of proteolytic enzymes on the pharmacokinetics of antibiotics].
    Author: Kivman GIa, Butylina LV, Rykov AS, Geĭtman IIa.
    Journal: Antibiotiki; 1975 Oct; 20(10):929-33. PubMed ID: 1211890.
    Abstract:
    The effect of chemotripsin on the pharmacokinetics of ampicillin as dependent on the drug dose and the administration intervals was studied on rats using the method of the experiment design. With the use of the method it was found that intramuscular injections of chemotripsin to rats in doses of 3, 4.5, 6, 8 and 10 mg/kg, 0.5, 1, 1.5 and 2 hours before intramuscular administration of ampicillin in doses of 10, 20, 35, 75 and 100 mg/kg caused a simple effect inducing an increase in the antibiotic levels in the blood and organs, when the enzyme and antibiotic were present simultaneously in the animal organism for an hour. The increase in the antibiotic levels in the rat organs due to simultaneous presence of chemotripsin and ampicillin the animal organism for 2 hours was less pronounced
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