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  • Title: Partial liquid ventilation with low dose of perflubron and a low stretch ventilation strategy improves oxygenation in a rabbit model of surfactant depletion.
    Author: Nakamura T, Tamura M.
    Journal: Biol Neonate; 2002; 82(1):66-9. PubMed ID: 12119544.
    Abstract:
    To demonstrate the efficacy of partial liquid ventilation (PLV) with a low dose of perflubron (PFB), severe lung injury model followed surfactant-depleted rabbits underwent PLV with either moderate tidal volume (V(T)) and high positive end-expiratory pressure (PEEP) or high V(T) and low PEEP. PLV with low-dose PFB was effective in alleviating hypoxia in a severe lung injury model if adequate PEEP was applied. We concluded that the addition of a low dose of PFB might be beneficial to a low stretch ventilation strategy, which allows a less aggressive approach to achieve adequate oxygenation with a possible reduction in further lung injury.
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