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  • Title: Signaling the pathway to regeneration.
    Author: Snider WD, Zhou FQ, Zhong J, Markus A.
    Journal: Neuron; 2002 Jul 03; 35(1):13-6. PubMed ID: 12123603.
    Abstract:
    Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.
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