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  • Title: Functional selectivity for glycerol of the nodulin 26 subfamily of plant membrane intrinsic proteins.
    Author: Wallace IS, Wills DM, Guenther JF, Roberts DM.
    Journal: FEBS Lett; 2002 Jul 17; 523(1-3):109-12. PubMed ID: 12123814.
    Abstract:
    The nodulin-like intrinsic protein (NIP) subfamily of water and solute channels in plants is named for nodulin 26 of legume nodules. Two NIPs, soybean nodulin 26 and Lotus japonicus LIMP2, show a distinct functional profile with a low intrinsic osmotic water permeability (P(f)) and the ability to flux uncharged polyols such as glycerol. NIPs have a conserved signature sequence within the 'aromatic/arginine' region that forms the selectivity filter for major intrinsic proteins. This sequence is a hybrid of glyceroporin and aquaporin residues as well as exhibiting substitutions unique to the NIP subfamily. Site-directed mutagenesis of a conserved tryptophan in helix 2 of LIMP2 shows that this is a major determinant of glycerol selectivity.
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