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  • Title: Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets.
    Author: Broekman MJ, Handin RI, Cohen P.
    Journal: Br J Haematol; 1975 Sep; 31(1):51-5. PubMed ID: 1212435.
    Abstract:
    The distribution of fibrinogen, platelet factor 4 (heparin-neutralizing factor) and factor XIII amongst subcellular fractions of human platelets was determined. It was found that fibrinogen and platelet factor 4 peaked sharply in the region of the density gradient previously shown to be heavily enriched with alpha-granules. By contrast, factor XIII, fibrin-stabilizing factor, was found exclusively in the supernatant.
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