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  • Title: [Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].
    Author: Korbi S, Trimeche M, Sriha B, Yacoubi MT, Hmissa S, Mokni M, Delvenne P, Boniver J, Rammeh S.
    Journal: Ann Pathol; 2002 Apr; 22(2):96-101. PubMed ID: 12124490.
    Abstract:
    The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.
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