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  • Title: [Gonadostatin and gonadocrinin, polypeptides of ovarian origin with hypophysiotropic activity].
    Author: Ying SY, Guillemin R.
    Journal: C R Seances Acad Sci D; 1979 Nov 19; 289(13):943-6. PubMed ID: 121254.
    Abstract:
    Crude acetic acid extract of Rat ovaries pretreated with pregnant mare serum (PMSG) contains native peptides with two types of separable biological activities: one, molecular weight greater than 10,000 dalton inhibits the secretion of both LH and FSH as stimulated by luteinizing hormone releasing factor (LRF) in a pituitary monolayer culture system and is referred to as gonadostatin; the other, less than 3,500 dalton, stimulates the secretion of gonadotropins and is designated as gonadocrinin. The biological activities of ovarian gonadocrinin can be competitively inhibited by an LRF-analog-antagonist, D-Phe2, D-Trp6-LRF. These ovarian peptides may participate in physiological control of pituitary LH/FSH secretion.
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