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  • Title: Kottamides A-D: novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae.
    Author: Appleton DR, Page MJ, Lambert G, Berridge MV, Copp BR.
    Journal: J Org Chem; 2002 Jul 26; 67(15):5402-4. PubMed ID: 12126438.
    Abstract:
    Kottamides A-D (1-4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using 15N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.
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