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  • Title: Blastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity.
    Author: Falcão RP, Garcia AB, Marques MG, Simões BP, Fonseca BA, Rodrigues ML, Foss NT.
    Journal: Leuk Res; 2002 Sep; 26(9):803-7. PubMed ID: 12127554.
    Abstract:
    We report the findings of three new cases of a distinct clinicopathologic natural killer (NK) cell malignancy characterized by cutaneous, nodal and bone marrow infiltration by CD3-CD4+CD56+ NK blastic cells. Tumor cells were detected in bone marrow and in peripheral blood smears and showed finely distributed nuclear chromatin with nucleoli and a moderate amount of cytoplasm. Epstein-Barr virus (EBV) DNA was negative in the two tested cases. The immunophenotypes determined by flow cytometry were identical concerning mCD3-cytCD3-CD4+weakCD56+ HLA-DR+. The TCR was in germline configuration in the two cases tested. NK cell activity was demonstrated only in one out of the two cases tested. The negative reactions with alpha-naphthyl-acetate-esterase (ANAE), CD11b and CD14 strongly suggested that the tumor cells were not of the monocytic lineage.
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