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  • Title: The interaction of rheumatoid factor with hepatitis B surface antigen-antibody complexes.
    Author: Markenson JA, Daniels CA, Notkins AL, Hoofnagle JH, Gerety J, Barker LF.
    Journal: Clin Exp Immunol; 1975 Feb; 19(2):209-17. PubMed ID: 1212797.
    Abstract:
    A solid phase radioimmunoassay was developed in which the hepatitis B surface antigen was adsorbed to the surface of plastic beads. When the antigen-coated beads were incubated with human IgG antibody against hepatitis B surface antigen, immune complexes were formed on the solid phase surface. IgM rheumatoid factor was found to bind to the hepatitis B surface antigen-antibody complexes but not to the antigen or the IgG antibody alone. Since both hepatitis B surface antigen-antibody complexes and rheumatoid factor are commonly present in type B viral hepatitis, it is suggested that rheumatoid factor may play a role in the pathogenesis of this viral disease in man.
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