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  • Title: [Age-related peculiarities of the effect of angiotensin-2 on some hemodynamic indices].
    Author: Pugach BV.
    Journal: Farmakol Toksikol; 1975; 38(4):427-30. PubMed ID: 1213128.
    Abstract:
    Changes occurring in some aspects of the hemodynamics following intravenous administration of different doses of angiotensin-2 were studied in tests staged on adult and old rabbits of both sexes. The older animals are shown to be more sensitive to this drug, for in them low doses (0.01, 0.1 gamma/kg) produced a significant elevation of the arterial pressure. On introduction of such doses the older animals more often demonstrate an accretion of the cardiac output. Introduction of the same doses to adult rabbits is more frequently attended by a rise of the total peripheral resistance. Upon administration of large doses of angiotensin-2 (1, 5 gamma/kg) the adult and older rabbits present more often a rise of the total peripheral resistance.
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