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  • Title: [Influence of low doses of a heparin-urea complex on the aggregation of thrombocytes and the fibrinolytic activity of blood in intravenous infusion and in in vitro experiments].
    Author: Kudriashov BA, Patorova VE, Liapina LA.
    Journal: Farmakol Toksikol; 1975; 38(4):441-4. PubMed ID: 1213132.
    Abstract:
    An addition in in vitro experiments of a heparin-urea (HU) complex to a thrombocyte rich plasma completely blocked the onset of the thrombocytes aggregation, induced by thrombin, and reduced the degree of aggregation caused by adenosine-diphosphate. An intravenous administration of a 0.01% HU complex solution to rats 5 minutes after injection also blocked the thrombocytes aggregation induced by thrombin. The effect of the HU complex on the thromocytes aggregation proceeded against the background of a significantly delayed blood clotting time and an activation of of a fermentative and non-fermentative fibrinolysis, emerging after introduction of the heparin-urea complex.
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