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  • Title: [Clinical significance of expression of the smooth muscle actin-alpha and CD34 antigen in mesangial cells in glomerulonephritis].
    Author: Chebotareva NV, Proppe D, Rudolf P, Kozlovskaia LV.
    Journal: Ter Arkh; 2002; 74(6):27-31. PubMed ID: 12136478.
    Abstract:
    AIM: To assess clinical implications of expression of alpha-smooth-muscle actin (ASMA) and CD34 as markers of activation and transformation of mesangial cells. MATERIAL AND METHODS: ASMA and CD34 expression was investigated with indirect enzyme immunoassay with addition of the complex alkaline phosphatase-antiphosphatase, mean number of stained (expressing) mesangial cells per 1 glomerulus were estimated in 47 renal tissue biopsies from patients with different morphological types of glomerulonephritis and 9 biopsies of the kidneys removed for different tumors (control). RESULTS: Mean expression of ASMA (11.0 +/- 3.5) was significantly higher in GN proliferative types than in non-proliferative ones and controls. In patients with proliferative nephritis ASMA expression correlated with clinical signs of nephritis activity. CD34 was expressed similarly in patients with proliferative and non-proliferative nephritis and in controls. CD34 was higher in biopsies with higher degree of sclerosis in the kidney than in the biopsies with moderate sclerosis. CONCLUSION: ASMA and CD34 expression by mesangial cells in renal biopsies from GN patients can be used for evaluation of the disease activity and prognosis.
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