These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prolonged suppression of insulin release by insulin-induced hypoglycemia: demonstration by C-peptide assay.
    Author: Horwitz DL, Rubenstein AH, Reynolds C, Molnar GD, Yanaihara N.
    Journal: Horm Metab Res; 1975 Nov; 7(6):449-52. PubMed ID: 1213648.
    Abstract:
    Pancreatic beta cells secrete the proinsulin connecting peptide (C-peptide) and insulin on an equimolar basis. The C-peptide can thus be used as an indicator of endogenous insulin secretion in the presence of exogenously administered insulin. Using this approach, we have shown suppression of endogenous insulin release in healthy subjects during hypoglycemia induced by intravenous infusion of porcine insulin. Moreover, the suppression persists after the plasma glucose returns to fasting levels, suggesting that the recovery of beta cells from the effects of hypoglycemia is not immediate.
    [Abstract] [Full Text] [Related] [New Search]