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  • Title: [In vivo studies on the metabolism of pyrimidine nucleosides (author's transl)].
    Author: Dahnke HG, Mosebach KO.
    Journal: Hoppe Seylers Z Physiol Chem; 1975 Oct; 356(10):1565-74. PubMed ID: 1213673.
    Abstract:
    3H-labelled metabolites were determined in the perchloric acid-soluble fraction of blood plasma and liver of adult male Wistar rats, following the application of [5 - 3H]uridine. Ten minutes after the injection of uridine, only 20% of the total 3H activity of the plasma could be attributed to [3H]uridine. The remaining radioactivity was found chiefly in [3H]uracil (40%) and 3H2O (20%). In the liver, at 10 min, [3H]-uridine and [3H]uracil together accounted for less than 0.5% of the total radioactivity; about 70% of the radioactivity was due to [3H]beta-alanine, and 15% to 3H2O. 45 min after the injection, 70% of the radioactivity in the plasma was due to 3H2O, whereas uridine and uracil represented about 4% and 6%, respectively. At this time, about 55% of the radioactivity in the liver was due to [3H]beta-alanine, about 40% to 3H2O, and about 5% to unidentified metabolites; [3H]uridine and [3H]uracil were not observed. A comparison of the rate of catabolism of [5-3H]-uridine, [5-3H]cytidine and [6-3H]thymidine showed that cytidine is degraded in the organism 25 times more slowly than uridine or thymidine. The biological half lives for the total degradation of the [3H]nucleosides to 3H2O, based on the values in the plasma, were: uridine 1.1 h; thymidine 1.3 h; cytidine 25 h. Furthermore, the turnover time of exogenous uridine in the plasma was found to be 9 min, which gives a half life of 6 min for the metabolism of exogenous uridine to uracil.
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