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  • Title: [Clinicopathological study of salivary duct carcinoma].
    Author: Shimizu A, Yamane M, Ito H, Araki S, Yoshida T, Suzuki M.
    Journal: Nihon Jibiinkoka Gakkai Kaiho; 2002 Jun; 105(6):727-31. PubMed ID: 12138700.
    Abstract:
    Salivary duct carcinoma (SDC) was first described by Kleinsesser in 1968 and was classified as an independent entity by the 1991 Revised World Health Organization. It is a rare but highly malignant tumor. We reviewed pathology in 49 cases of salivary adenocarcinoma, and diagnosed 6 cases as SDC. All had a rapidly enlarged mass in the parotid gland. All were men, and 4 involved facial palsy and metastasis to cervical lymph nodes. Fine needle aspiration biopsy was conducted in 3 cases, but none was diagnosed as SDC. Two had chemotherapy, but showed no effect. All underwent surgery, but only 1 survived more than 4 years. Immunohistochemically, none showed s-100 protein. Four showed PCNA and p53 protein. Highly positive cells of PCNA and p53 were found around comedo necrosis.
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