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  • Title: Clinical, microbiological, and economic benefit of a change in antibiotic prophylaxis for cardiac surgery.
    Author: Spelman D, Harrington G, Russo P, Wesselingh S.
    Journal: Infect Control Hosp Epidemiol; 2002 Jul; 23(7):402-4. PubMed ID: 12138981.
    Abstract:
    Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.
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