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  • Title: Histologic bile duct invasion by a mass-forming intrahepatic cholangiocarcinoma.
    Author: Hirohashi K, Uenishi T, Kubo S, Yamamoto T, Tanaka H, Shuto T, Yamasaki O, Horii K, Kinoshita H.
    Journal: J Hepatobiliary Pancreat Surg; 2002; 9(2):233-6. PubMed ID: 12140612.
    Abstract:
    BACKGROUND/PURPOSE: Although curative surgical resection provides the best chance of long-term survival for patients with intrahepatic cholangiocarcinoma, the presence of bile duct invasion decreases postoperative survival rates in patients with mass-forming intrahepatic cholangiocarcinoma. We carried out this study to determine a surgical strategy for patients with bile duct invasion of these tumors. METHODS: Forty-one patients with mass-forming intrahepatic cholangiocarcinoma were classified as either having bile duct invasion ( n = 26) or not having bile duct invasion ( n = 15). Clinicopathologic findings, including postoperative outcomes, were compared between these two groups. RESULTS: Perineural invasion, lymphatic invasion, and a positive resection margin were more frequent in patients with ductal invasion. Patients with ductal invasion had lower survival rates than those without ductal invasion. CONCLUSIONS: Intraoperative frozen section examination of the bile duct stump to confirm a clear resection margin is required in patients with mass-forming tumors. Resection of the extrahepatic bile duct should be considered when tumor cells are identified at the surgical margin of the resected bile duct.
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