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  • Title: Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa.
    Author: Ploutno A, Shoshan M, Carmeli S.
    Journal: J Nat Prod; 2002 Jul; 65(7):973-8. PubMed ID: 12141855.
    Abstract:
    Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel. Homonuclear and heteronuclear 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.
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