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  • Title: ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus.
    Author: Block S, Stévigny C, De Pauw-Gillet MC, de Hoffmann E, Llabrès G, Adjakidjé V, Quetin-Leclercq J.
    Journal: Planta Med; 2002 Jul; 68(7):647-9. PubMed ID: 12143003.
    Abstract:
    The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
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