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  • Title: Synthesis of a 2-arylsulphonylated tryptophan: the antibacterial activity of bovine lactoferricin peptides containing Trp(2-Pmc).
    Author: Haug BE, Andersen J, Rekdal O, Svendsen JS.
    Journal: J Pept Sci; 2002 Jul; 8(7):307-13. PubMed ID: 12148780.
    Abstract:
    A modified tryptophan, beta-[2-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-indol-3-yl]alanine, Trp(2-Pmc) = Tpc has been synthesized. Replacement of tryptophan in a bovine lactoferricin model peptide with the modified tryptophan resulted in peptides with a substantially increased antibacterial activity against Escherichia coli and Staphylococcus aureus. The most active peptides against each bacterial strain displayed minimal inhibitory concentrations of 7.5 microg/ml.
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