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  • Title: [The mechanism of inactivation of the bird erythrocyte genome. III. Pathways of terminal differentiation of erythrocytes].
    Author: Gazarian KG, Kul'minskaia AS.
    Journal: Ontogenez; 1975; 6(1):31-8. PubMed ID: 1214984.
    Abstract:
    Under the conditions of acute phenylhydrazine anemia in pigeons, early erythroblasts develop in reticulocytes with basophilic cytoplasm directly by passing the stages of polychromatophilic and ortochromic erythroblasts. During the maximum activity of bone marrow erythropoiesis stimulated by anemia over 80% of reticulocytes develop in such a way. A hypothesis is put forward to the effect that there exist in birds two alternative pathways of erythropoiesis: the main pathway which ensures the slow repopulation of blood by erythrocytes under normal conditions and the reserve pathway which opens for a short time under anemia and ensures rapid increase of the erythrocyte titer in blood up to its normal value.
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