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  • Title: [New muscle formation following transplantation of muscle treated with trypan blue].
    Author: Polezhaev LV.
    Journal: Ontogenez; 1975; 6(4):338-47. PubMed ID: 1215008.
    Abstract:
    The sources and mechanism of muscle formation de novo were investigated under the transplantation of skeletal muscle fibers treated in the 1% water solution of Trypan Blue for 48 hrs after Levander under skin and in omentum in rabbits and rats. In some cases the pieces of Trypan Blue stained muscles were placed in the diffusion chambers. Besides, 3H-thymidine autoradiography was used. It was established that after the above described treatment the muscles appeared morphologically as necrotized. They do not develop in the diffusion chambers in which cells do not penetrate. Under the transplantation of such muscles under skin and in omentum, they are phagocytized and disintegrate and in the close neighbourhood myoblasts arise which transform into muscle tubules and differentiated cross-striated muscle fibers. If prior to the transplantation the rats--recipients were labeled by 3H-thymidine, the muscle fibers formed de novo with the labeled nuclei, i. e. from the recipient cells in omentum where there are no muscles, apparently from polyblasts. Under the definite experimental conditions, myoblasts appear to arise from cells of non-myogenic origin by means of induction.
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