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  • Title: Thyrotoxicosis due to metastatic papillary thyroid cancer in a patient with Graves' disease.
    Author: Basaria S, Salvatori R.
    Journal: J Endocrinol Invest; 2002; 25(7):639-42. PubMed ID: 12150341.
    Abstract:
    Thyrotoxicosis resulting from functional thyroid cancer metastases is extremely rare, and is mostly caused by follicular cancer. The lesions causing thyrotoxicosis are usually bulky and extensive. We report here a patient with Graves' disease and concomitant papillary thyroid cancer who developed metastases causing symptomatic thyrotoxicosis. His serum titers of thyroid stimulating Ig (TSIs) were elevated. We believe that TSIs were responsible for thyrotoxicosis by stimulating hormonogenesis in the metastatic lesions.
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