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  • Title: In vitro assessment of gatifloxacin spectrum and potency tested against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae isolates from the Asia-Western Pacific component of the SENTRY antimicrobial surveillance program (1998-1999).
    Author: Bell JM, Turnidge JD, Pfaller MA, Jones RN.
    Journal: Diagn Microbiol Infect Dis; 2002 Aug; 43(4):315-8. PubMed ID: 12151193.
    Abstract:
    Fluoroquinolones, especially the newer agents, have an increased role in the management of respiratory tract infections worldwide. In the SENTRY Antimicrobial Surveillance Program for the Asia-Pacific Region for 1998 and 1999, 630 Streptococcus pneumoniae, 583 Hemophilus influenzae and 274 Moraxella catarrhalis isolates were examined to determine the comparative activity of the new fluoroquinolone, gatifloxacin, compared with those of ciprofloxacin, levofloxacin and trovafloxacin. Gatifloxacin was highly active against all three species. Decreased susceptibility (MIC >/=2 microg/mL) to gatifloxacin was noted in only seven strains of S. pneumoniae (3 of which were resistant); in three strains of H. influenzae (MIC >/= 0.12 microg/mL), and 2 M. catarrhalis (MIC > 2 microg/mL).
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