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Title: Preparation of orthogonally protected chitosan oligosaccharides: observation of an anomalous remote substituent effect. Author: Liew ST, Wei A. Journal: Carbohydr Res; 2002 Aug 16; 337(14):1319-24. PubMed ID: 12151213. Abstract: Orthogonally protected chitosan tetrasaccharides were synthesized in a convergent fashion by trichloroacetimidate activation. The anomeric substituent at the reducing end of the disaccharide acceptor has a remarkably strong influence on glycosidic coupling; a thiophenyl-substituted disaccharide was observed to be an unusually poor glycosyl acceptor in comparison with the corresponding allyloxy-substituted disaccharide.[Abstract] [Full Text] [Related] [New Search]