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  • Title: [Mathematical model of trans-sarcomere exchange of calcium ions and Ca2+-dependent control of smooth muscle contractile activity].
    Author: Kosterin SO, Miroshnychenko MS, Pryluts'kyĭ IuI, Davydovs'ka TL, Tsymbaliuk OV.
    Journal: Ukr Biokhim Zh (1999); 2002; 74(2):128-33. PubMed ID: 12152305.
    Abstract:
    The mathematical model of smooth muscles contractile activity Ca(2+)-dependent control has been proposed on the base of Ca ions trans-sarcomal exchange biochemical mechanisms interpretation in myocytes. While analysing the model the conclusion should be made that kinetic parameters changes (in relation to Ca ions) Mg2+, ATP-dependent calcium pump of plasma membrane--Michaelis constant Km and transport process maximal velocity Vmax-render the effect on the character of the intracellular calcium transients and profile of full mechanokinetic curve. As well one more conclusion has been made that plasma membrane Mg2+, ATP-dependent calcium pump, which kinetic parameters under the physiologic conditions are subjected to modulation as the result of metabolic, pharmacologic and physico-chemical factors fulfills the essential role in supplying Ca(2+)-dependent control of the smooth muscles contractile response full cycle.
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