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  • Title: [Oxygen dependent metabolism of neutrophils and monocytes in patients with unstable angina and its correction with preductal].
    Author: Romanov VA, Kratnov AE, Romanova NV, Khrustalev OA.
    Journal: Patol Fiziol Eksp Ter; 2002; (2):15-7. PubMed ID: 12152422.
    Abstract:
    Oxygen-dependent metabolism of neutrophils and monocytes and antioxidant defense and heparin and trimetasidine effects on them were studied in 39 patients with unstable angina. All the patients showed a significant activation of neutrophils and monocytes by NBT-test, insignificant one by chemiluminescence in active serum superoxide dismutase and reduced total antioxidative serum potential. There was also a moderate rise in the level of CIC in enhanced HBT-test. Heparin in unstable angina pectoris produced stimulation of oxygen-dependent metabolism of neutrophils and monocytes, ischemic damage to the myocardium was not changed. This was observed after treatment with preductal indicating antioxidant properties of this drug.
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