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  • Title: [Changes of free amino acids in seminal plasma with vasectomy and reanastomosis of the vas deferens (author's transl)].
    Author: Nakayama K, Murakami N, Miura K, Shirai M, Ando K.
    Journal: Nihon Funin Gakkai Zasshi; 1981 Apr; 26(2):12-6. PubMed ID: 12158576.
    Abstract:
    In 11 cases undergoing vasectomy for the purpose of contraception, and in 2 vasectomized men receiving reanastomosis to regain conceptive potential, their semen samples were obtained before and after the operation and changes in seminal levels in a variety of amino acids were compared. Seminal levels of amino acids were determined by employing auto amino acid analyzer (JLC-6AH). Preoperative values for seminal amino acids in their 11 patients underwent notable changes with vasectomy. The most prominent among the general decreases was a drop by as much as 51% for proline, followed by 48.9% for aspartic acid, over 30% each for threonine, glycine, alanine, valine, leucine, lysine, and arginine, 29.9% for isoleucine, 29% for serine, 26.4% for phenylalanine, 24.1% for tyrosine, and 23.6% for glutamine. On the other hand, of the 2 patients undergoing reanastomosis of the vas deferens, the 1 who achieved impregnation after the operation showed remarkably low preoperative levels in almost all seminal plasma amino acids. After the operation and with the appearance of sperm in the semen, however, amino acid levels rose; at 4 months, when impregnation was confirmed, some varieties were noted at a 1.5-9.5 fold increase over preoperative values. In the other reanastomosis patient, although sperm did not appear at the 2 week postoperative sampling, values of various amino acids in the seminal plasma had risen 1.4-6.3 times the preoperative level. The fact that vasectomy caused various free amnio acids to decrease markedly in the seminal plasma may tell us that amino acids, equivalent in amount to their decreases, probably had originated from the testicles and epididymides located above the vas deferens. On the other hand, reanastomosis of the vas deferens caused various free amino acids within the fluid of the testicles and epididymides to flow into the semen, elevating the level of total seminal amino acids. Therefore, when increases in free amino acids in seminal plasma do not accompany the appearance of sperm, it may be interpreted that some problems in the testicles or epididymides are responsible for impairing otherwise successful reanastomosis of the vas deferens. Thus, it seems appropriate to conclude that success or failure of reanastomosis of the vas deferens can be judged by determining amino acids in seminal plasma without resorting to seminalvesiculography. (author's)
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