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  • Title: [Studies on inhibitors of blood coagulation and fibrinolysis during use of oral contraceptives].
    Author: Miyaji K.
    Journal: Nihon Funin Gakkai Zasshi; 1982 Apr; 27(2):242-50. PubMed ID: 12158577.
    Abstract:
    The authors studied antithrombin 3 (AT3), alpha1 antitrypsin (alpha1 AT), and alpha2 macroglobulin (alpha2 M) in Japanese women taking oral contraceptives (OCs). These are the results. 1) In women receiving combined OCs (mestranol 0.1 mg and norethisterone 2 mg) for 20 days every cycle, serum AT3 activity had markedly decreased after completion of the 1st series. In successive series, no significant difference was observed between the values before and after treatment. AT3 activity was almost equal to that of control values in the 3rd-5th series of treatments and then displayed a tendency to decrease. Changes in plasma AT3 activity was almost the same as those in the serum. 2) A marked decrease in serum and plasma AT3 activity was also observed for women taking low dosage combined OCs (mestranol 0.05 mg and norethisterone 1 mg). It seemed ineffective to reduce the estrogen component of the OCs for purposes of preventing the decrease in AT3 activity. 3) Use of norethisterone alone, 5 mg/day for 20 days, did not induce remarkable changes in both serum and plasma AT3 activity, although it is considered 1 of the estrogenic gestagens. 4) AT3 activity in Japanese women was considerably higher than that reported in Western women. This perhaps could explain the low incidence of thromboembolic disease in Japanese women. 5) Serum alpha1 AT had significantly increased after the initial cycle and kept high concentrations for the succeeding 24 series. 6) OCs had no influence on the concentrations of alpha2 M and FDP in serum. (author's modified)
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