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  • Title: Castleman's disease: an unusual cause of mediastinal mass and anemia.
    Author: Candoni A, Michelutti T, Morelli A, Geromin A, Damiani D, Scott C, Fanin R.
    Journal: Clin Ter; 2002; 153(3):217-9. PubMed ID: 12161984.
    Abstract:
    We reported a case of thoracic localized, mixed variant, Castleman's Disease (angiofollicular lymph node hyperplasia) with a favourable clinical course presenting with mediastinal mass, microcytic anemia, mild thrombocytosis, polyclonal hyper-gammaglobulinaemia and without symptoms. Castleman's Disease must be always considered in the differential diagnosis of solitary mediastinal masses. Transthoracic fine needle aspiration cytology is usually nondiagnostic; in fact, cytologically, Castleman's Disease can be confused with other mediastinal lymphoproliferative disorders (such as thymomas or lymphomas). The optimal therapeutic approach is unknown but a complete surgical resection is treatment of choice for localized disease.
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