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Title: Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma? Author: Khan RB, Shi W, Thaler HT, DeAngelis LM, Abrey LE. Journal: J Neurooncol; 2002 Jun; 58(2):175-8. PubMed ID: 12164690. Abstract: Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Using a case-controlled retrospective study, matching patients treated with HD-MTX with or without IT-MTX, we found no difference in survival, disease control, or neurotoxicity.[Abstract] [Full Text] [Related] [New Search]