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  • Title: [Characteristics of messenger RNA for interferon and of interferon-inducing RNA isolated from Newcastle disease virus infected cells].
    Author: Orlova TF, Georgadze II, Kognovitskaia AI, Karmanov PA.
    Journal: Vopr Virusol; 1975; (4):412-6. PubMed ID: 1216831.
    Abstract:
    Two kinds of RNA capable of producing interferon in a heterologous cell system occur in the cells producing interferon in response to induction by Newcastle disease virus. One of them has messenger activity for interferon and is presented by a single-stranded structure with sedimentation constant of 10-22 S. This RNA appears to belong to cellular messenger RNA. The other is capable of inducing interferon production by heterogenous cells, resistant to treatment with RN-ase and has sedimentation constant greater than 35 S. In our opinion, this RNA is the primary replicative RNA of the virus-inducer.
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