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  • Title: [Hemostasis suppression by a combination of heparin and acetylsalicylic acid].
    Author: Wamhoff D, Schmechel H.
    Journal: Z Gesamte Inn Med; 1975 Sep 15; 30(18):178-80. PubMed ID: 1216936.
    Abstract:
    The effect of a combined application of acetylsalicylic acid and heparin on haemostasis is examined on 7 healthy test persons. Apart from the change of the plasmatic coagulation and the platelet function by the pharmaca a prolongation of the bleeding time which is larger than the values of the individual application can be established. In the in-vitro-experiment could be proved that the prolonged bleeding time is based on the prevented by acetylsalicylic acid release of the heparin neutralising factor 4 from the platelets. An improvement of the therapeutic effect of heparin when at the same time acetylsalicylic acid is given is discussed.
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