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  • Title: Minreg: inferring an active regulator set.
    Author: Pe'er D, Regev A, Tanay A.
    Journal: Bioinformatics; 2002; 18 Suppl 1():S258-67. PubMed ID: 12169555.
    Abstract:
    Regulatory relations between genes are an important component of molecular pathways. Here, we devise a novel global method that uses a set of gene expression profiles to find a small set of relevant active regulators, identify the genes that they regulate, and automatically annotate them. We show that our algorithm is capable of handling a large number of genes in a short time and is robust to a wide range of parameters. We apply our method to a combined dataset of S. cerevisiae expression profiles, and validate the resulting model of regulation by cross-validation and extensive biological analysis of the selected regulators and their derived annotations.
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