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  • Title: Acute cor pulmonale due to microscopic tumour embolism as the first manifestation of hepatocellular carcinoma.
    Author: Gutiérrez-Macías A, Barandiarán KE, Ercoreca FJ, De Zárate MM.
    Journal: Eur J Gastroenterol Hepatol; 2002 Jul; 14(7):775-7. PubMed ID: 12169988.
    Abstract:
    Microscopic pulmonary tumour embolism is a rare cause of pulmonary hypertension. In most of the reported cases, symptoms develop over several days or weeks in patients previously diagnosed with malignant diseases. In our case, a 41-year-old man with an unremarkable medical history presented with respiratory failure that led to death less than 48 h from the onset of symptoms. Autopsy revealed massive microscopic pulmonary tumour embolism and a multifocal hepatocellular carcinoma. This case report is exceptional because it describes a very rapid clinical progression, and because acute cor pulmonale was the first manifestation of a previously undiagnosed neoplastic disease.
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