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  • Title: High correlation between salivary MHPG and CSF MHPG.
    Author: Reuster T, Rilke O, Oehler J.
    Journal: Psychopharmacology (Berl); 2002 Aug; 162(4):415-8. PubMed ID: 12172695.
    Abstract:
    RATIONALE: Determination of 3-methoxy-4-hydroxy-phenylglycol (MHPG) as a major metabolite of noradrenaline may reflect changes in noradrenergic activity dependent on psychiatric illness and drug therapy. OBJECTIVE: This study was designed to investigate the relationship between CSF and salivary MHPG, and thus the utility of saliva MHPG as a marker for CSF MHPG. METHOD: Twenty-one paired samples of saliva and CSF were assayed for MHPG by solid-phase extraction and HPLC-ED. RESULT: Salivary MHPG was highly positively correlated with CSF MHPG ( P<0.001). CONCLUSION: This finding supports the use of salivary MHPG as an index for CSF MHPG, and enhances the usefulness of salivary MHPG measurements as a non-invasive approach for clinical studies investigating noradrenergic systems.
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