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  • Title: [The antiparkinson activity of gludantan (preliminary report)].
    Author: Kamianov IM, Andrezinia RA.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1975; 75(6):910-6. PubMed ID: 1217399.
    Abstract:
    A total of 33 patients with different forms of parkinsonism were treated by a new original antiparkinsonic preparation Gludantane synthesized at the Institute of Organic Synthesis of the Latvian Academy of Sciences. The authors demonstrated a higher antiparkinsonic activity of this drug compared to cholinolytical preparations and midantane and the possibility of achieving a better therapeutical effect in a combination of gludantane with other antiparkinsonic drugs. The preparation appeared to be effective in different etiological forms of parkinsonism. However, its highest effect was in the rigid and rigid-trembling forms, and less effective in trembling-rigid forms and not effective in the trembling form. Gludantane is practically devoid of side-effects and is well tolerated by patients.
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