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  • Title: [The mechanism of the diuretic action of chlorazicin].
    Author: Vorontsov VV.
    Journal: Biull Eksp Biol Med; 1975 Nov; 80(11):53-7. PubMed ID: 1218263.
    Abstract:
    Diuretic and natriuretic action of chloracizine in rats was not associated with its direct influence on the kidney and was accompanied by increase in the plasma volume, by a fall of the hematocrite index and of the total plasma proteins. A study of endogenous creatinine and of osmotic-free water clearance showed the diuretic action of chloracizine to be mainly due to the increase of glomerular filtration and to reduction of the relative proximal reabsorption.
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