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  • Title: In vitro and in vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic.
    Author: Yun HJ, Min YH, Lim JA, Kang JW, Kim SY, Kim MJ, Jeong JH, Choi YJ, Kwon HJ, Jung YH, Shim MJ, Choi EC.
    Journal: Antimicrob Agents Chemother; 2002 Sep; 46(9):3071-4. PubMed ID: 12183275.
    Abstract:
    The in vitro and in vivo activities of DW286, a novel fluoronaphthyridone with potent antibacterial activity, were compared with those of ciprofloxacin, gemifloxacin, sparfloxacin, and trovafloxacin. Against gram-positive bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Enterococcus faecalis, the in vitro activity of DW286 was stronger than that of any other reference antibiotic. Against gram-negative bacteria, the activity of DW286 was similar to those of trovafloxacin and gemifloxacin but was weaker than that of ciprofloxacin. In a mouse systemic infection caused by three S. aureus strains, including methicillin-resistant S. aureus and quinolone-resistant S. aureus (QRSA), DW286 demonstrated the most potent activity, as found in vitro. Specially, DW286 is >or=8-fold more active against QRSA than the other fluoroquinolones. And the 50% protective doses for DW286 were correspondent with the in vitro activities.
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