These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining.
    Author: Scheepers PT, Coggon D, Knudsen LE, Anzion R, Autrup H, Bogovski S, Bos RP, Dahmann D, Farmer P, Martin EA, Micka V, Muzyka V, Neumann HG, Poole J, Schmidt-Ott A, Seiler F, Volf J, Zwirner-Baier I.
    Journal: Toxicol Lett; 2002 Aug 05; 134(1-3):305-17. PubMed ID: 12191893.
    Abstract:
    Methods for the assessment of exposures to diesel exhaust were evaluated, including various biomarkers of internal exposure and early biological effects. The impact of possible biomarkers of susceptibility was also explored. Underground workers (drivers of diesel-powered excavators) at an oil shale mine in Estonia were compared with surface workers. Personal exposures to particle-associated 1-nitropyrene (NP) were some eight times higher underground than on the surface. Underground miners were also occupationally exposed to benzene and polycyclic aromatic hydrocarbons, as indicated by excretion of urinary metabolites of benzene and pyrene. In addition, increased O(6)-alkylguanine DNA adducts were detected in the white blood cells of underground workers, suggesting higher exposure to nitroso-compounds. However, no differences between underground and surface workers were observed in the levels of other bulky DNA adducts determined by 32P-postlabelling, or in DNA damage. The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results.
    [Abstract] [Full Text] [Related] [New Search]