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Title: Enhancement of methacholine-stimulated guanosine 3':5'-cyclic monophosphate formation in supersensitive guinea pig vasa deferentia. Author: Hsu C, Leighton HJ, Westfall TC, Brooker G. Journal: J Cyclic Nucleotide Res; 1976; 2(5):359-64. PubMed ID: 12194. Abstract: Decentralization of the guinea pig vas deferens resulted in supersensitivity of the contractile response to methacholine. Methacholine also elevated cyclic GMP to a greater extent in the decentralized vas deferens than in sham-operated controls. Decentralization did not alter basal cyclic AMP or cyclic GMP content. These observations are analogous to the enhanced responsiveness of cyclic AMP formation in supersensitive beta adrenergic systems.[Abstract] [Full Text] [Related] [New Search]