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  • Title: [Vitamin D deficiency in children with chronic diseases evaluated because of osteopenia].
    Author: Reyes ML, Hernández MI, Palisson F, Talesnik E.
    Journal: Rev Med Chil; 2002 Jun; 130(6):645-50. PubMed ID: 12194687.
    Abstract:
    BACKGROUND: Chronic diseases in children may determine limited sun exposure, use of drugs, and other risk factors of osteopenia. OBJECTIVE: To evaluate vitamin D deficiency and their risk factor, in children with chronic diseases with suspected osteopenia. METHODS: We measured bone mineral density, bone remodeling markers, calcium, phosphate, parathormone, and 25 hydroxyvitamin D levels, and wrist X-ray. RESULTS: We found 8 children of 25 with suspected osteopenia, with biochemical abnormalities suggestive of vitamin D deficiency. All children had low levels of 25 hydroxyvitamin D, 5 had reduced bone mineral density, 4 had hyperparathyroidism, 2 had hyperphosphatasemia, and 1 hypocalcemia and hypophosphatemia. None had rickets. DISCUSSION: Osteopenia in chronic sick children is due to multiple factors; however, vitamin D deficiency is a preventable disorder. We recommend that all children with a chronic disease with risk factors for vitamin D deficiency should be monitored with 25 hydroxyvitamin D serum levels.
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