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  • Title: Numb: "Adapting" notch for endocytosis.
    Author: Jafar-Nejad H, Norga K, Bellen H.
    Journal: Dev Cell; 2002 Aug; 3(2):155-6. PubMed ID: 12194846.
    Abstract:
    During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.
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