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  • Title: Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting.
    Author: Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD.
    Journal: Dev Cell; 2002 Aug; 3(2):271-82. PubMed ID: 12194857.
    Abstract:
    The sorting of transmembrane proteins (e.g., cell surface receptors) into the multivesicular body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT protein complexes. The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20. The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes.
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