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  • Title: A new mechanism for membrane iron transport in Pseudomonas aeruginosa.
    Author: Schalk IJ, Abdallah MA, Pattus F.
    Journal: Biochem Soc Trans; 2002 Aug; 30(4):702-5. PubMed ID: 12196169.
    Abstract:
    Various biochemical and biophysical studies have demonstrated the existence of a novel iron-uptake mechanism in Pseudomonas aeruginosa, different from that generally described for ferrichrome and ferric-enterobactin in Escherichia coli. This new iron-uptake mechanism involves all the proteins generally reported to be involved in the uptake of ferric-siderophore complexes in Gram-negative bacteria (i.e. the outer membrane receptor, periplasmic binding protein and ATP-binding-cassette transporter), but differs in the behaviour of the siderophore. One of the key features of this process is the binding of iron-free pyoverdin to the outer membrane receptor FpvA in conditions of iron deficiency.
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