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  • Title: Differential effectiveness of newer and older antidepressants appears mediated by an age effect on the phenotypic expression of depression.
    Author: Parker G.
    Journal: Acta Psychiatr Scand; 2002 Sep; 106(3):168-70. PubMed ID: 12197852.
    Abstract:
    OBJECTIVE: A possible mechanism whereby the serotonin reuptake inhibitor (SSRI) antidepressants may not (overall) be as effective as the tricyclic (TCA) antidepressants is explored. METHOD: Clinical psychiatrists rated the effectiveness of past antidepressant medications in a clinical panel study of patients with a major depressive disorder, with 200 having previously received a TCA and 219 an SSRI. RESULTS: Analyses indicated decreased SSRI effectiveness with age in those with the melancholic subtype. TCA effectiveness appeared uninfluenced by age and depressive subtype. CONCLUSION: Findings suggest why the broader-based TCAs may be more effective than the SSRIs in implicating age and depressive subtype influences.
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