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  • Title: Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features.
    Author: Piana S, Cavazza A, Pedroni C, Scotti R, Serra L, Gardini G.
    Journal: Arch Pathol Lab Med; 2002 Sep; 126(9):1104-5. PubMed ID: 12204062.
    Abstract:
    Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.
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