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  • Title: [A quantitative analysis of renal pathology in the children with anaphylactoid purpura nephritis (APN)].
    Author: Wu XC, Yi ZW, He XJ, Dang XQ, Zhao WL.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2000 Aug 28; 25(4):403-5. PubMed ID: 12206018.
    Abstract:
    OBJECTIVE: To provide the theoretical value for the treatment and prognostic judgement of APN. METHODS: All cases were scored on the pathologic change of glomeruli and tubules. RESULTS: The pathologic scores of glomeruli in 30 cases were as follows: no one on Grade 0; 6(20%) on Grade 1; 17(56.7%) on Grade 2 and 7 (23.3%) on Grade 3. The pathologic scores of tubule were: Grade 0 was 2(6.7%); Grade 1 was 6(20%); Grade 2 was 14(46.7%); Grade 3 was 8(26.7%). There was positive correlation between glomerulus and tubule pathologic degree(r = 0.783, P < 0.01). The pathologic score of nephrotic syndrome in clinical manifestation was higher than that of non-nephrotic syndrome(P < 0.01). There was no significant difference in glomerular pathologic score between the simple urinary protein group and acute glomerulonephritis(AGN) group(P > 0.05), but tubular pathologic score in simple urinary proteins group was higher than that of AGN and essential hematuria group (P < 0.01, P < 0.05). The pathologic score of kidney(including glomerulus and tubule) was positively correlated with the disease course(r = 0.563, P < 0.01), but not with serum urea nitrogen and creatinine(r = 0.281, r = 0.236, P > 0.05). CONCLUSION: Serious tubular pathologic changes(not only glomerular pathologic change, but also tubular pathologic change in the APN children) were found in the patients with nephrotic syndrome and simple urinary proteins. Long-term urinary protein and the recurrence of the disease may be the important risk factor in kidney pathologic of APN.
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