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  • Title: From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
    Author: Ratcliffe PJ.
    Journal: Blood Purif; 2002; 20(5):445-50. PubMed ID: 12207089.
    Abstract:
    The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the alpha subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal.
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